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Nancy Guthrie disappearance: Savannah Guthrie says ‘we still believe’ as FBI investigates DNA


Last Update
February 16, 2026, 6:45 AM EST

A recovered glove matching the type worn by the subject seen in surveillance video outside Nancy Guthrie’s home the morning she was taken has the DNA profile of an unknown male, the FBI said Sunday. A task force was awaiting forensic results in the case.

Covered by: Stephen SoraceSophia ComptonMichael RuizChristina Dugan RamirezPeter D’AbroscaGreg Wehner and Landon Mion

FAST FACTS

  • The search for Nancy Guthrie entered its third week on Sunday. The 84-year-old disappeared from her home in Tucson, Arizona, 16 days ago.
  • Authorities still have no suspects or persons of interest, though Pima County Sheriff Chris Nanos said more law enforcement operations are expected in the coming days.
  • Savannah Guthrie shared a message of hope in a new video she posted Sunday, marking two weeks since her mother’s disappearance.
  • glove with a DNA profile of an unknown male has been recovered, and appears to match the pair worn by a subject seen in surveillance video outside Nancy Guthrie’s home, the FBI said Sunday.
  • The FBI released a description of the suspect seen in a mask and gloves tampering with the doorbell camera in front of Nancy Guthrie’s home in the early morning hours of Feb. 1 around the time she went missing. The suspect is described as a male between 5’9” – 5’10” tall, with an average build and was seen carrying a 25-liter “Ozark Trail Hiker Pack” backpack.
  • The FBI increased its reward to $100,000 for information leading to the location of Nancy Guthrie or the arrest and conviction of anyone involved in her disappearance.

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BREAKING NEWS9 hours ago

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Glove DNA in Nancy Guthrie case expected to be entered into CODIS soon

Glove DNA in Nancy Guthrie case expected to be entered into CODIS soon

Photos released on Feb. 10, 2025, show a “subject” on Nancy Guthrie’s property. (Provided by FBI)

An FBI official told Fox News Digital DNA recovered from a glove believed tied to the suspect in the Nancy Guthrie case is still undergoing quality control testing at the sheriff’s private lab in Florida after being sent from Tucson on Feb. 12.

Once that process is complete, the profile is expected to be entered into the FBI’s Combined DNA Index System, or CODIS, in the near future – possibly as soon as tonight – which could determine whether it matches anyone in the national database.

When asked whether more than one suspect could be involved, the official pointed to FBI Director Kash Patel’s comments on “Hannity” last week referencing “persons of interest,” indicating investigators are not ruling out the possibility of multiple individuals.

Fox News Digital’s Michael Ruiz contributed to this report.

Posted by Greg Wehner

1 hour ago

Canvass of gun stores conducted several days ago, federal official says

Canvass of gun stores conducted several days ago, federal official says

Brandon Bell/Getty Images

A federal law enforcement official said on Monday that agents conducted a canvass of gun stores “several days ago,” as federal and local authorities continue investigating Nancy Guthrie’sdisappearance.

The official told NBC News that while a canvass was done days ago, one was not conducted on Monday. The official said additional canvassing could be possible if a specific lead warrants such action.

“Things are still very fluid, and we are out on many leads,” the official told the outlet.

The official also warned that too much public exposure or reporting on specific law enforcement steps, “whether accurate or inaccurate, gives the perpetrator a window into the investigation.”

“That’s not helpful,” the official said.

Posted by Landon Mion

2 hours ago

Expert says small pieces of ‘degraded DNA’ on glove near Guthrie home could be key to solving case

Expert says small pieces of 'degraded DNA' on glove near Guthrie home could be key to solving case

Ty ONeil/AP Photo

An expert said even tiny pieces of DNA — which she called ‘DNA confetti’ — found on a glove discovered by investigators near Nancy Guthrie’s home could help solve her disappearance.

Colleen Fitzpatrick, the president and founder of Identifinders Forensic Genealogy who has worked on several high-profile cases, said the DNA on the glove is a crucial element in solving the case and that a DNA match will likely come from either a database of previously convicted criminals or a genealogical link to the abductor.

She told Fox 10 that investigators are likely waiting to see if they find a hit in the Combined DNA Index System (CODIS), the database that could connect the DNA to an offender in a previous crime.

“They’re waiting to see if they have a CODIS hit and if do not. If they do, okay, that way, if they don’t, then my guess is they’re gonna do the genealogy,” Fitzpatrick told the outlet.

Fitzpatrick said “touch DNA” is typically what would be found on a glove like the one found near Guthrie’s house and that advancements in detection technology make the job of law enforcement easier.

“Our ability to sense DNA, detect DNA, is getting better and better,” Fitzpatrick said. “So it could be quite a tiny bit of DNA, or you know, it could be a lot if somebody held it for a long time.”

“At least with genealogy, we’ve been very successful at very highly degraded DNA,” Fitzpatrick said, noting that a match is not less likely even if the DNA on the glove has degraded from sitting in the desert climate for days. “I call it ‘DNA confetti’ — little tiny pieces. That doesn’t bother us because the markers we use are very small, so we can use little small pieces of DNA.”

That DNA is being sent through CODIS, and Fitzpatrick said the next likely step is focusing on genes and the matches potentially identified through ancestry databases.

“It’s not just one person — do you match or not? You have a whole network of people that you can kind of put together in a big Sudoku puzzle,” Fitzpatrick said. “If they’re related to you, they’re related to each other through marriage or blood. So you start building the trees, connecting them.”

Posted by Landon Mion

6 hours ago

Sheriff says 40,000 to 50,000 tips pour in as Guthrie probe expands

Sheriff says 40,000 to 50,000 tips pour in as Guthrie probe expands

Graphic showing Nancy Guthrie’s picture superimposed over a low-flying helicopter in Arizona on Feb. 2, 2026. (Fox News Digital/Christina Dugan Ramirez; Facebook/Savannah Guthrie)

Law enforcement officials have received between 40,000 and 50,000 tips in the Nancy Guthrie investigation, Pima County Sheriff Chris Nanos told NBC affiliate KVOA in Tucson on Monday.

Earlier in the day, Nanos told the station over 30,000 leads had been routed to both his office and the FBI, adding that investigators believe they are making progress in the case.

He also said several hundred law enforcement officers are working on the investigation.

Posted by Greg Wehner

6 hours ago

Sheriff says he spoke out to defend Guthrie family from unfair attacks

Sheriff says he spoke out to defend Guthrie family from unfair attacks

Pima County Sheriff Chris Nanos (Sejal Govindarao/AP Photo)

Pima County Sheriff Chris Nanos told NBC that he issued a public message about the Guthrie family out of concern they were being unfairly targeted amid the investigation into Nancy Guthrie’s disappearance.

Earlier in the day, Nanos announced that the Guthrie family – including siblings and spouses – have been cleared as possible suspects, describing them as “nothing but cooperative and gracious” and emphasizing that they are victims in the case.

In a text message later explaining his decision to speak out, Nanos wrote, “Because sometimes we forget we’re human and we hurt and kindness matters. It is every cop’s duty to stand up and be that voice for our victims.”

“I’m not going to sit in silence when others are attacking the innocent. Isn’t that what the badge represents?” he added, reiterating that suggestions to the contrary are “not only wrong, it is cruel.”

Posted by Greg Wehner

6 hours ago

Former FBI official details strict DNA steps in Guthrie case

Former FBI official details strict DNA steps in Guthrie case

Scientist analyzing DNA result for check genetics and forensics science. (iStock)

Retired supervisory FBI Agent Jason Pack says the DNA process in the Nancy Guthrie case is moving under urgency but bound by strict protocols, explaining that evidence tested at a private Florida lab must pass multiple reviews in Arizona before it can be entered into the FBI’s national CODIS database.

Pack confessed to Fox News Digital he is not a DNA expert, but as an agent, he learned the process.

In the Guthrie case, he said the DNA is being tested by a private forensic laboratory in Florida, though the investigation belongs to Pima County, Arizona.

“That matters, because DNA does not move straight from a private lab to the FBI,” he said. “There’s no doubt they know the urgency and are fast tracking without cutting corners. We heard tonight that they are finishing their quality checks at the private lab.”

Pack said the process involves investigators in Arizona first sending the biological evidence to the Florida lab for testing. During testing, the lab workers will extract the DNA and create a DNA profile. The new profile is not a name, but instead is a series of numbers based on genetic markers.

He added that the testing of the DNA can take days or weeks, depending on the condition of the evidence.

Once testing is complete, the DNA profile is not sent to the FBI, but instead to Pima County because they own the case. While the lab has the DNA profile, they cannot upload it into the national system. Instead, it has to be transmitted securely and handled by a certified CODIS laboratory, which is usually a government lab authorized by the FBI.

Pima County would then normally send the profile to Arizona’s state crime lab for review, Pack explained, which checks to make sure the testing followed FBI standards and that the documentation is complete.

“Only after that review, or if Pima County formally asks the FBI to take responsibility sooner, can the DNA move to the FBI,” he said. “If the FBI assumes submission responsibility, it can upload the profile directly into the national database. That removes one layer, but it still isn’t instant. The FBI still conducts its own quality checks.”

Once the profile is in the CODIS, it can only be compared to DNA already in the system, like those from convicted offenders and DNA from other crime scenes. If the person connected to the case has never been in CODIS, there will not be a match.

“Because the lab is in Florida and the case belongs to Arizona, there are multiple handoffs before anything goes national,” Pack said. “Even when everything moves smoothly, investigators are usually talking about weeks, not days. If the DNA goes through the full Arizona review process first, a month or more is realistic.

“That doesn’t mean nothing is happening. It means the system is moving carefully, under urgency, and the way it was designed to work,” he added.

Posted by Greg Wehner

9 hours ago

Former FBI analyst believes Guthrie suspect amateur, Savannah’s latest message tailored to him

Former FBI analyst believes Guthrie suspect amateur, Savannah's latest message tailored to him

An undated photo of Nancy Guthrie and Savannah Guthrie was provided by NBC in response to the disappearance of the 84-year-old mother of the “Today” show host. (Courtesy of NBC)

A former FBI agent who worked in behavioral analysis told Fox News Digital that he believes Savannah Guthrie’s latest Instagram video was directed towards a suspect who could be an amateur criminal feeling the heat of a now-massive investigation.

Savannah Guthrie began her latest video by saying that after two weeks of her mother, Nancy Guthrie, 84, being missing, she and the rest of the Guthrie family are not giving up. She then made a direct plea to her mother’s alleged abductor.

“It’s never too late. You are not lost or alone, and it is never too late to do the right thing,” she said in the video. “And we are here. We believe in the essential goodness of every human being. And it’s never too late.”

Jonny Grusing worked in the FBI’s Denver Division for 25 years, investigating violent crimes, missing persons, serial killers and more. He coordinated the behavior analysis unit for the division for 13 of those years.

Find out what Grusing had to say about Savannah Guthrie’s latest message.

This is an excerpt from a story by Fox News Digital’s Peter D’Abrosca.

Posted by Greg Wehner

10 hours ago

Sheriff says investigators ‘stuck’ on motive in Guthrie case

Sheriff says investigators ‘stuck’ on motive in Guthrie case

This image released by the FBI show an armed individual appearing to have tampered with the camera at Nancy Guthrie’s front door the morning of her disappearance in Tucson, Arizona, Sunday, February 1, 2026. (L) An undated photo of Nancy Guthrie provided by NBC in response to the disappearance of the 84 year-old mother of Today Show host, Savannah Guthrie. (Provided by FBI; Courtesy of NBC)

Pima County Sheriff Chris Nanos said investigators still do not know the motive behind the apparent kidnapping of 84-year-old Nancy Guthrie, calling it one of the biggest unanswered questions in the case.

In an interview with the Daily Mail, Nanos said authorities believe the incident was a kidnapping – not a burglary gone wrong – but acknowledged they remain “stuck” when it comes to understanding why it happened.

“And that’s what makes me say this is a kidnapping,” Nanos said. “The motivation for it is where we get stuck, right? Is it for money? I mean, we had the one demand where they asked for money. But is it really for money, or is it for revenge for something?”

Posted by Greg Wehner

11 hours ago

Damaged vehicle removed from home raided in Nancy Guthrie probe

Damaged vehicle removed from home raided in Nancy Guthrie probe

A map showing the relative locations of police activity in the Catalina foothills and the Nancy Guthrie’s home in Tucson, Arizona, Friday, February 13, 2026. (Fox News)

A vehicle parked outside a home in the Catalina foothills that was raided by the FBI on Friday was towed away Monday, Fox News Digital confirms.

The FBI executed a late-night search warrant at the home Friday. The damaged vehicle – which had significant front-end damage – remained at the property over the weekend before a tow truck removed it Monday. Authorities have not said whether it is connected to the investigation.

Pima County Sheriff Chris Nanos said after the raid that a man detained during a traffic stop Friday night in connection with the Nancy Guthrie investigation was investigators’ “person of interest” and was later released. No arrests have been made and “no sign of Nancy was found,” Nanos said.

Posted by Greg Wehner

11 hours ago

Sheriff Nanos responds to ‘haters’ in Nancy Guthrie probe

Sheriff Nanos responds to ‘haters’ in Nancy Guthrie probe

Pima County Sheriff Chris Nanos (Kelly Presnell/Arizona Daily Star via AP)

Pima County Sheriff Chris Nanos said he has a “thick skin” when it comes to “haters” accusing him of botching the investigation into Nancy Guthrie’s disappearance, dismissing claims he mishandled evidence or blocked the FBI as “so far-fetched.”

In an interview with the Daily Mail, Nanos rejected online criticism that his office released the crime scene too early or interfered with federal authorities, saying his deputies spent nearly 20 hours processing the home before the FBI arrived.

“My officers were there for almost 20 hours, and they processed their scene, got it done, and brought in all the evidence,” he said. “Then the FBI came and did their thing.”

Nanos also bristled at reports suggesting he prevented the FBI from obtaining key evidence. “That’s just so far-fetched,” he said. “Why would I do that? It makes no sense.”

He added that any ransom notes or related materials were immediately turned over to federal authorities, noting the FBI’s expertise in hostage negotiations as the search for 84-year-old Nancy Guthrie continues.

Posted by Greg Wehner

BREAKING NEWS12 hours ago

Sheriff says Guthrie family members eliminated as suspects

Sheriff says Guthrie family members eliminated as suspects

Savannah Guthrie and her siblings Annie and Cameron made an emotional plea on Instagram asking anyone with information about their mother Nancy Guthrie’s disappearance to come forward. (Instagram/@SavannahGuthrie/Today)

Pima County Sheriff Chris Nanos said the Guthrie family has been cleared as suspects in the investigation into the disappearance of 84-year-old Nancy Guthrie.

“To be clear…the Guthrie family  –  to include all siblings and spouses –  has been cleared as possible suspects in this case,” Nanos said. “The family has been nothing but cooperative and gracious and are victims in this case.

“To suggest otherwise is not only wrong, it is cruel,” he added. “The Guthrie family are victims plain and simple…please, I’m begging you the media to honor your profession and report with some sense of compassion and professionalism.”

Fox News’ Matt Finn asked Nanos if DNA helped clear the Guthrie family, noting that on Friday, DNA swabs of the family were sent to the private lab the sheriff is using.

“Not going there…they are victims and I will not stand quiet while they are re-victimized,” Nanos told Finn. “It is not just my duty, it is every cop’s duty to stand up and be the voice for victims.”

Posted by Greg Wehner